COVID-19

Publications and Guidelines

29.04.2020

Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study

Among household contacts of infected patients the secondary attack rate was unrelated to age. Children and adolescents were equally likely to be infected as older adults (infection rate 7.4% in children <10 years vs overall proportion of 6.6%).

Comment Taskforce Knowledge-Management Covid-19

Interessante Daten zur heiss diskutierten Frage, ob Kinder seltener infiziert werden oder nur seltener symptomatisch werden. Diese Studie unterstützt Letzteres.

#clinical #infectious diseases #epidemiology
29.04.2020

Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis

A systematic review and meta-analysis of 13 studies with 3027 patients corroborating that male, aged over 65 and smoking patients might face a greater risk of developing into the critical or mortal condition and the comorbidities such as hypertension, diabetes, cardiovascular disease or respiratory diseases could also greatly affect the prognosis of COVID-19.

#clinical #review #ICU #infectious diseases #internal medicine
29.04.2020

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

Case-Series of histopathology findings from 26 patients who died from COVID-Infection in China.

Comment Taskforce Knowledge-Management Covid-19

Die Biopsien zeigen ein gemischtes Bild aus akuter Tubulus Nekrose des schwerkranken und intensiv-pflichtigen Patienten und virus-spezifischen akuten inflammatorischen Veränderungen. Mikroangiopathische Veränderungen wurden in dieser Autopsieserie nicht gefunden.

#nephrology
29.04.2020

SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2.

Recombinant human ACE-2 inhibits protects kidney organoids from infection with COVID-19 virus particles.

Comment Taskforce Knowledge-Management Covid-19

Diese Studie offeriert zwei Perspektiven: (1) Testung von rekombinantem ACE-2 als passiver Schutz vor Infektionen, (2) Organoidkulturen von vielen Individuen zur Identifizierung von (genetischen) Prädispositionen für COVID-19 Infektionen.

#nephrology
28.04.2020

Estimating Survival of Hospitalized COVID-19 Patients from Admission Information

The Authors of this preprint propose a survival probability calculator based on the presentation of 5'233 COVID-19 patients. Thia tool may help in critical decision support

#general #ICU
28.04.2020

Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis.

In this meta-analysis, including 2'389 COVID-19 patients from 13 studies, the authors report that cardiac injury is associated with mortality, need for ICU care, and severity of disease

#clinical #ICU #cardiology
28.04.2020

Imaging Publications in the COVID-19 Pandemic: Applying New Research Results to Clinical Practice

The authors of this article analyse examples from the current literature on CT diagnosis of COVID-19 to illustrate how underlying factors such as study design and study population characteristics affect the results and their meaning.

Comment Taskforce Knowledge-Management Covid-19

Von der Studie aus Wuhan zum Einzelfall in Bern? Dieser höchst lesenswerte Artikel erklärt worauf man achten muss, wenn man die Resultate einer wissenschaftlichen Studie im klinischen Alltag anwenden möchte.

#imaging #medical education #review #diagnosis #radiology
28.04.2020

International Expert Consensus Statement on Chest Imaging in Pediatric COVID-19 Patient Management: Imaging Findings, Imaging Study Reporting and Imaging Study Recommendations

This consensus statement addresses imaging of COVID-19 children. The publication includes recommendations on the use of radiographs and CT in the diagnostic work up of paediatric patients and discusses the role of structured reporting for both plain film and CT.

Comment Taskforce Knowledge-Management Covid-19

Alle bisherigen Empfehlungen zur Rolle der Bildgebung bei COVID-19 haben sich auf erwachsene Patienten beschränkt. Diese Publikation zur Bildgebung für Kinder mit COVID-19 schliesst diese Lücke und bietet eine gute Ressource für alle, die sich auf die Eigenheiten der Bildgebung von pädiatrischen COVID-19 Patienten vorbereiten wollen.

#consensus statement #diagnosis #imaging #radiology
28.04.2020

Presymptomatic Sars-Cov-2 Infections and Transmission in a Skilled Nursing Facility

Authors conducted two serial point-prevalence surveys, 1 week apart, in about 89 residents of a nursing home facility in the Washington state in the US. Twenty-three days after the first positive SARS-CoV-2 PCR resident at this nursing facility, 57 of 89 residents (64%) tested positive for SARS-CoV-2. More than half of residents with positive test results were asymptomatic at the time of testing (but developed symptoms lager in 89%) and most likely contributed to transmission.

Comment Taskforce Knowledge-Management Covid-19

Dieser rasch verlaufende Ausbruch der SARS-CoV-2 Infektion in einem Pflegeheim anfangs März wurde sorgfältig aufgearbeitet. Erneut starke Indizien, dass infizierte Personen vor Auftreten von Symptomen ansteckend sein können.

#epidemiology
27.04.2020

Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence

In this case series in france, the authors have seen among the 107 first consecutive confirmed COVID-19 patients admitted in ICU for pneumonia, an unexpected high number of pulmonary embolism (i.e. 22 patients, 20.6%) during their stay. This number was twice as high as compared to a control period or compared to influenza cases. More data is needed to evaluate whether Covid-19 patients are at increased risk for pulmonary embolism and whether heparin prophylaxis regimen should be adapted.

#clinical #prevention #cardiovascular #ICU #pneumology