COVID-19

Publications and Guidelines

01.04.2020

Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19

In this “Consensus Statement on Reporting of CT Findings Related to COVID-19”, the Radiological Society of North America (RSNA) offers aids in recognizing, reporting, and communicating CT imaging findings of COVID-19 pneumonia to facilitate the management and care of patients.

Comment Taskforce Knowledge-Management Covid-19

This useful publication has the potential to improve the diagnostic accuracy and clarity of radiology reports and increase their practical value during this pandemic.

#imaging #review #consensus statement #radiology
01.04.2020

Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China

Currently the largest case series of pediatric patients reported from China, with 713 virologically confirmed and 1412 supected cases, respectively. 13% of patients were asymptomatic, 84% had mild to moderate disease, 3% had "severe" disease as defined by supplemental O2 requirement. There were no fatal cases.

Comment Taskforce Knowledge-Management Covid-19

Children with suspected COVID-19 tended to be more severely affected than patients with virologically confirmed disease. This suggests that that the "suspected" group may have been contaminated by other viral etiologies, most notably RSV bronchiolitis.

#pediatrics #epidemiology #infectious diseases
01.04.2020

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.

199 hospitalized individuals in China with laboratory-confirmed COVID-19 infection and signs of respiratory impairment were randomized (1:1) to receive LPV/r for 14 days or standard of care alone. No difference in time to clinical improvement or mortality was found between the 2 groupes.

Comment Taskforce Knowledge-Management Covid-19

The majority of participants were late in infection adn there was limited power to evaluate the potential benefits of LPV/r in early disease

#treatment #ICU #infectious diseases
01.04.2020

Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis

In a nationwide analysis of 1590 hospitalized patients with laboratory-confirmed COVID-19 infection across China, the number of comorbidities (mainly hypertension , diabetes and malignancy) was associated with the composite primary endpoint (admission to intensive care unit, or invasive ventilation, or death). The HR was 1.79 (95%CI 1.16-2.77) among patients with at least one comorbidity and 2.59 (95%CI 1.61-4.17) among patients with two or more comorbidities.

Comment Taskforce Knowledge-Management Covid-19

Despite a relatively short follow-up time and the self-reported nature of information on comorbidities, this study shows that a thorough assessment of comorbidities may help establish risk stratification of patients with Covid-19 upon hospital admission.

#clinical #infectious diseases
01.04.2020

SARS-CoV-2 Infection in Children

The majority of hospitalized children <16 years (168 of 171; 98%) at Wuhan Children's Hospital (90% identified in family clusters) presented with mild or asymptomatic disease. Fever, cough, pharyngeal erythema in roughly 45% of cases, but chest CT with evidence of pneumonia in 65%.

Comment Taskforce Knowledge-Management Covid-19

patients with Covid-19 upon hospital admission

#imaging #pediatrics #infectious diseases
01.04.2020

Timely blood glucose management for the outbreak of 2019 novel coronavirus disease (COVID-19) is urgently needed

For COVID-19 patients with diabetes, tailored therapeutic strategies and optimal glucose control should be formulated. Blood glucose should be controlled for all patients during hospitalization to monitor the progress of illness and avoid aggravation. During the follow-up period after discharge, blood glucose homeostasis should be maintained continuously. The popularization of Internet and smartphones ensure remote medical consultation for patients who are not advised to go to the hospital.

#treatment #diabetes
31.03.2020

Neuraxial procedures in COVID-19 positive parturients - a review of current reports

Data on parturient patients with COVID-19 is scarce and is limited to case reports. COVID-19 patients may have a higher risk for respiratory compromise and viral meningitis/encephalitis. This review and expert opinion concludes that neuraxial anesthesia is still the safest anaesthesia form for most patients despite these circumstances. However, anaesthesiologists should be aware of potential lower platelet counts.

#treatment #opinion #anaesthesiology #obstetrics & gynaecology
31.03.2020

Analysis and Prediction of COVID-19 Patients’ False Negative Results for SARS-CoV-2 Detection with Pharyngeal Swab Specimen: A Retrospective Study

False negative test results: In a cohort with COVID-19 and available CT and blood results, initial test results for SARS-CoV-2 were negative in 52.2%.

#diagnosis #radiology
31.03.2020

Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility

This review summarizes the clinical and preclinical evidence for the existence of elevated plasmin(ogen) in important comorbid conditions of COVID-19, like hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction, and highlights the importance of plasmin-induced proteolytic cleavage of the SARS-COV-2 S protein and fibrin in the development of COVID-19. Plasminogen might be a possible common denominator in the understanding of the mechanisms for high morbidity and mortality of patients with important comorbid conditions, could be an independent factor for risk stratification and a possible therapeutic target in COVID-19.

#general #internal medicine #physiology
31.03.2020

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

Retrospective study raising awareness for gastrointestinal symptoms in COVID-19 patients. Analyzing the largest cohort of patients with GI symptoms to date, this study found novel characteristics of COVID-19, including increased family clustering and liver injury, severe/critical type tendency and higher rate of body temperature >38.5°C, holding important implications for healthcare workers not to overlook on this possible form of presentation in COVID-19.

#gastrointestinal #epidemiology