COVID-19

Publications and Guidelines

14.04.2020

Implication of non-alcoholic fatty liver diseases (NAFLD) in patients with COVID-19: a preliminary analysis

In this study, the authors examined the liver injury patterns and implication of non-alcoholic fatty liver diseases (NAFLD) on clinical outcomes in Chinese with COVID-19.

Comment Taskforce Knowledge-Management Covid-19

Die (nicht-alkoholische) Fettlebererkrankung (NAFLD) hat eine stetig steigender Prävalenz und scheint, wie andere bereits identifizierte und mit ihr vergesellschaftete Erkrankungen (z.B. Diabetes mellitus Typ 2) ein erhöhtes Risiko für schwerere Verläufe bei Covid-19 mit sich zu bringen.

#clinical #general #hepatology
14.04.2020

Chest Computed Tomography for Detection of Coronavirus Disease 2019 (COVID-19): Don't Rush the Science

In this opinion piece, the authors express concern that rushing to publish positive results on imaging in COVID-19 carries a risk of biased science and distribution of premature conclusion on the ability and role of imaging during this pandemic.

Comment Taskforce Knowledge-Management Covid-19

Gut Ding will Weile haben. Das Spannungsfeld zwischen Einhaltung wissenschaftlicher Qualitätsstandards und dem Druck neue Erkenntnisse zur Diagnose von COVID-19 rasch zu veröffentlichen illustriert am Beispiel der Radiologie.

#diagnosis #imaging #opinion #medical education #radiology
14.04.2020

Differences in Clinical and Imaging Presentation of Pediatric Patients with COVID-19 in Comparison with Adults

According to this small study, paediatric patients with COIVD-19 tend to have milder symptoms as well as fewer and different radiologic findings compared to adult patients. On CT for example, bronchial wall thickening was more frequently seen in children with COIVD-19 than in adults.

Comment Taskforce Knowledge-Management Covid-19

Kinder sind nicht kleine Erwachsene. Dieses Axiom der Pädiatrie scheint auch für die COVID-19 zu gelten, wie dieser Vergleich von radiologischen Befunden bei Erwachsenen und Kindern aufzeigt.

#imaging #diagnosis #radiology #pediatrics
14.04.2020

Delayed access or provision of care in Italy resulting from fear of COVID-19

Italian Children's Hospitals report > 80% reduction of ER visits in March 2020 compared with earlier years with an increase in deaths due to conditions unrelated to COVID-19 because of delayed diagnosis and therapy

Comment Taskforce Knowledge-Management Covid-19

Kollateralmorbitität und -mortalität bei Kindern wegen Resourcenverschiebung und Zurückhaltung der Eltern, Notfallstationen rechtzeitig aufzusuchen.

#prevention #clinical #pediatrics
13.04.2020

Prediction of the clinical outcome of COVID-19 patients using T lymphocyte subsets with 340

Analysis of lymphocyte subsets as predicor for outcome. Including a webbased analytical tool

Comment Taskforce Knowledge-Management Covid-19

Abfall von T Helfer Zellen als relevanter Prädiktor für Mortalität

#diagnosis #general #clinical #emergency medicine #immunoresponses
12.04.2020

cases from Wuhan, China: a retrospective cohort study and a web visualization too

Meta-Analysis of studies on gastra-intestinal symptoms in patients with COVID-19. GI symptoms are reported in up to a fith of patients tested positive for COVID-19, and in a substantial portion of patients GI symptomes were not acompanied by respiratory findings.

Comment Taskforce Knowledge-Management Covid-19

1) Auch bei alleinigen GI-Symptomen an COVID-19 denken 2)Der Nachweis von VirusRNA in Stuhlproben allein reicht noch nicht, um auch eine Infektiosität zu belegen (siehe das unten besprochene Paper von Wölfel et al, Nature 2020).

#diagnosis #review #general #gastrointestinal
12.04.2020

Covid 19 Clinical trials Summary

Systematic analysis of 301 planned and ongoing trials on Covid-19 listed in clinicaltrials.gov. Curent as of 4.4.2020. Trials are mostly interventional phase III trials with a large variety in recruitment targets. Most trials were added in the last week.

Comment Taskforce Knowledge-Management Covid-19

Die Übersicht veranschaulicht die dringend nötige Koordination von Studien zu COVID-19. Sind 45 verschiedene Studien zu Hydroxychloroquin wirklich sinnvoll?

#review #general
10.04.2020

The COVID-19 vaccine development landscape

Le et al. give an overview of the COVID-19 vaccine discovery by early April 2020. 73 condirmed and active vaccine candidates have been developed across the world, of whom 5 are already in clinical phase I studies. Overall, 56 (72%) are being developed by private/industry developers and 22 by the public/academic sector

Innerhalb von wenigen Monaten wurden 73 verschiedene, aktive Impfstoffe entwickelt, und einige werden schon in klinischen Studien evaluiert

#prevention #review #infectious diseases #epidemiology
10.04.2020

NAS letter suggests ‘normal breathing’ can expel coronavirus (anm: NAS: National Academy of Sciences)

Discussion of evidence showing possible distribution of SARS-COV-2 via aerosols and feces

Comment Taskforce Knowledge-Management Covid-19

Verbreitung von SARS-CoV-2 via Aerosole und Stuhl nicht ausgeschlossen.

#general
09.04.2020

Neonatal Resuscitation and Postresuscitation Care of Infants Born to Mothers with Suspected or Confirmed SARS-CoV-2 Infection

The presented approaches provide flexibility and allow perinatal health care providers and parents to determine the best options based on the assessment of risks and benefits, available personnel, space, case load, and resources. In the pandemic of COVID-19, the common ailments of neonates will remain higher on the differential diagnosis. However, the possibility of infection from SARS-CoV-2 should be considered in the ill infant for the foreseeable future. It is also of prime importance that health care providers protect themselves while providing the best care possible.

Comment Taskforce Knowledge-Management Covid-19

Gute Übersicht über Handlungsmassnahmen bei der neonatalen Versorgung zum Schutze des Neugeborenen sowie des geburtshilflichen Teams bei einer COVID-19-postiven Mutter.

#obstetrics & gynaecology #neonatology