COVID-19

Publications and Guidelines

08.04.2020

Urinalysis, but not blood biochemistry, detects the early renal-impairment in patients with COVID-19

Abnormal urinary findings are prevalent in COVID infected patients irrespective of their Serum Creatinine Level. Pathological Urinalysis is associated with more severe disease course.

Comment Taskforce Knowledge-Management Covid-19

Retrospektive Studie über Urinbefunde bei COVID-19 infizierten Patienten. Rund die Hälfte hatten relevante pathologische Befunde, v.a. Proteinurie und/oder Leukozyt-/Erythrozyturie. Erhöhtes Kreatinin und eingeschränkte Nierenfunktion war in dieser Studie selten und nicht mit den Urinbefunden assoziiert. Die Befunde könnten Ausdruck einer direkten zytopathischen COVID-Infektion der Niere sein. Ob es strukturelle Nephropathien triggert und langfristig relevant ist, bleibt abzuwarten.

#nephrology
08.04.2020

Kidney diseases in the time of COVID-19: major challenges to patient care

Brief overview about the prevalence and outcome of COVID infection in dialysis patients and kidney transplant recipients.

Comment Taskforce Knowledge-Management Covid-19

Nicht nur die Immunsuppression, sondern die Komorbiditäten und der häufige Kontakt zu Gesundheitsinsitutionen scheinen relevant.

#nephrology
08.04.2020

Clinical Trial for the Prevention of SARS-CoV-2 Infection (COVID-19) in Healthcare Personnel (EPICOS) (EPICOS)

This study aims to assess the efficacy of a daily single dose of tenofovir disoproxil fumarate (TDF) (245 mg)/ Emtricitabine (FTC) (200 mg), a daily single dose of hydroxychloroquine (HC) (200 mg), a daily single dose of TDF (245 mg)/FTC (200 mg) plus HC (200 mg) versus placebo, during 12 weeks in: (1) reducing the incidence of symptomatic disease and (2) reducing clinical severity COVID-19 among hospital healthcare workers aged 18 to 65 years in public and private hospitals in Spain. The trial plans to enroll 4'000 participants.

Comment Taskforce Knowledge-Management Covid-19

Healthcare workers are particularly at risk of SARS-CoV-2. This is one of the first prevention trials to reduce SARS-CoV-2 transmission using a drug.

#prevention
08.04.2020

Facemasks and Similar Barriers to Prevent Respiratory Illness Such as Covid-19: A Rapid Systematic Review.

Based on only few RCTs authors conclude that wearing facemasks can be very slightly protective against primary infection from casual community contact, and modestly protective against household infections when both infected and uninfected members wear facemasks. However, authors think that there is enough evidence to support the use of facemasks for short periods of time by particularly vulnerable individuals when in transient higher risk situations.

Comment Taskforce Knowledge-Management Covid-19

Probably the first rapid systematic review on the question whether and how much widespread use of facemasks may help to prevent respiratory illness such as SARS-CoV-2. Not surprising, there are only few well-designed studies addressing this question.

#prevention
08.04.2020

Coronavirus Disease 2019 (COVID‐19): Do Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect?

Cardiologists and infectiologists from the the Inselspital comment on the possible biphasic effect of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Covid-19.

Comment Taskforce Knowledge-Management Covid-19

Die Autoren stellen eine Hypothese auf, welche besagt, dass ACE Hemmer und Angiotensin-Rezeptor Blocker einerseit den Eintritt des Virus in die Zellen via ACE2 up-regulation begünstigen könnten. Andererseits wäre eine up-regulation des ACE2 bei bereits infizierten Patienten mit diesen Medikamenten erwünscht um das lungenschädigende Angiotensin II tief zu halten. Sicherlich muss eine solche Hypothese mittels Studien genau untersucht werden und bis dahin sollte nichts an der Medikation verändert werden.

#general #clinical #cardiovascular #infectious diseases
08.04.2020

Angiotensin Converting Enzyme 2: A Double-Edged Sword

The authors describe the bifunctional role of ACE2 as a “double-edged sword”, which turns off the renin-angiotensin system and leads to beneficial effects but also mediates unique susceptibility to lung and cardiovascular disease in COVID-19 patients by serving as the SARS-CoV-2 receptor.

#cardiovascular #pneumology
08.04.2020

Loss of smell and taste in combination

App based large scale UK study demonstrates that loss of smell accompanied 59% of SARS-CoV-2 positive cases, but only 18% of negative cases with similar other symptoms

Comment Taskforce Knowledge-Management Covid-19

Gut gemachte Studie unterstützt Berichte, dass SARS-CoV-2 Infektion deutlich häufiger mit akuter Anosmie assoziiert ist als andere virale Atemwegsinfektionen.

#general #clinical #infectious diseases
07.04.2020

Behavioral and Emotional Disorders in Children during the COVID-19 Epidemic

Clinginess, inattention, irritability and fear of asking questions about the epidemic are reported as major psychological reactions among children > 3 years of age in China.

Comment Taskforce Knowledge-Management Covid-19

Kinder in China reagierten in dieser Elternumfrage v.a. mit Anhänglichkeit, Aufmerksamkeitsstörung, Reizbarkeit und Angst Fragen zu stellen auf die veränderten Lebensbedingungen während des Lock-downs.

#general #pediatrics
06.04.2020

Predictor of COVID-19 infection

Ferguson and colleagues from the Imperial College London estimate with infection propagation models that, across 11 countries between 7 and 43 million individuals have been infected with SARS-CoV-2 up to 28th March, representing between 1.9% and 11.4% of the population. With current government interventions remaining in place, they estimated that interventions across all 11 countries will have averted 59,000 deaths up to 31 March [95% uncertainty range 21,000-120,000].

Comment Taskforce Knowledge-Management Covid-19

Ferguson and colleagues from the Imperial College London have done some serious modelling work to estimate how much government measures in 11 European countries reduced the basic reproduction number of SARS-CoV-2 infections. Also Switzerland is covered and the “lockdown” might have brought it down near 1 (with substantial uncertainty). They estimate that Swiss measures might have averted 340 deaths by March 31 [95% uncertainty range: 71 - 1,100].

#epidemiology
06.04.2020

Developing antibody tests for SARS-CoV-2

In response to the COVID-19 pandemic, laboratories are rushing to produce reliable antibody tests. Antibodies are markers of a previous infection and they can be found in a patient’s blood sample any time from about a week after the infection happened. The most highly anticipated expectation of antibody tests to COVID-19 is to understand how many cases of COVID-19 have actually occurred in a population.

Comment Taskforce Knowledge-Management Covid-19

Übersichtlicher Artikel zur Entwicklung, Verfügbarkeit und Rolle von zuverlässigen Antikörper-Tests für SARS-CoV-2.

#general #diagnosis #therapy