COVID-19

Publications and Guidelines

31.03.2020

Neuraxial procedures in COVID-19 positive parturients - a review of current reports

Data on parturient patients with COVID-19 is scarce and is limited to case reports. COVID-19 patients may have a higher risk for respiratory compromise and viral meningitis/encephalitis. This review and expert opinion concludes that neuraxial anesthesia is still the safest anaesthesia form for most patients despite these circumstances. However, anaesthesiologists should be aware of potential lower platelet counts.

#treatment #opinion #anaesthesiology #obstetrics & gynaecology
31.03.2020

Analysis and Prediction of COVID-19 Patients’ False Negative Results for SARS-CoV-2 Detection with Pharyngeal Swab Specimen: A Retrospective Study

False negative test results: In a cohort with COVID-19 and available CT and blood results, initial test results for SARS-CoV-2 were negative in 52.2%.

#diagnosis #radiology
31.03.2020

Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility

This review summarizes the clinical and preclinical evidence for the existence of elevated plasmin(ogen) in important comorbid conditions of COVID-19, like hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction, and highlights the importance of plasmin-induced proteolytic cleavage of the SARS-COV-2 S protein and fibrin in the development of COVID-19. Plasminogen might be a possible common denominator in the understanding of the mechanisms for high morbidity and mortality of patients with important comorbid conditions, could be an independent factor for risk stratification and a possible therapeutic target in COVID-19.

#general #internal medicine #physiology
31.03.2020

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

Retrospective study raising awareness for gastrointestinal symptoms in COVID-19 patients. Analyzing the largest cohort of patients with GI symptoms to date, this study found novel characteristics of COVID-19, including increased family clustering and liver injury, severe/critical type tendency and higher rate of body temperature >38.5°C, holding important implications for healthcare workers not to overlook on this possible form of presentation in COVID-19.

#gastrointestinal #epidemiology
31.03.2020

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic

State of the art review article about COVID-19 and cardiovascular disease

#guidelines #cardiovascular #cardiology
31.03.2020

Preventing a covid-19 pandemic: ACE inhibitors as a potential risk factor for fatal Covid-19

Sommerstein/Gräni from the Inselspital were questioning whether ACE inhibitors upregulate ACE2, the entry receptor for Sars-CoV2 and may worsen the course?

#prevention #treatment #cardiovascular #diabetes #cardiology
31.03.2020

Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers

Due to the concern of patients and healthcare providers regarding uncertainties with ACEI/ARBs in Covid-19, a statement was released: ACEI/ARBs should be continued and treatment should not be changed as no evidence is available that they do harm in Covid-19. ACEI/ARBs should be given according to established guidelines.

#guidelines #cardiology
31.03.2020

Recommendations for Endotracheal Intubation of COVID-19 Patients

Anesthesia induction is a precedure with a high risk of aerosolization of SARS-CoV-2. This article discribes how anesthesia induction should be modified in order to minmize this risk. This article is short and reflects the positions of the major societies

#treatment #guidelines #anaesthesiology
31.03.2020

COVID-19 pandemic: triage for intensive-care treatment under resource scarcity

Although not a being a scientific paper, this special article provides decision guidance for the allocation of ICU treatment in the face of scarce ressources with a potentially upcoming wave of COVID-19 patients requiring ICU support in Switzerland

#treatment #guidelines #ICU
30.03.2020

Joint Statement on Multiple Patients Per Ventilator

Several countries that face a mismatch between existing ventilatory infrastructure and demand for ventilator support of critical COVID-19 patients in ICU start developing custom-made solutions to overcome this problem. Some of these include ventilating two or more patients with the same ventilator. The Anaesthesia Safety Foundation (APSF) has released a statement that discourages these modifications and provides solid arguments against such solutions. This statement has been endorsed by several other major organizations.

#treatment #guidelines #ICU #anaesthesiology