COVID-19

Publications and Guidelines

05.05.2020

Maternal Death Due to COVID-19 Disease

This case series from Iran reports that among 9 pregnant women with severe COVID-19 disease, at the time of reporting, 7 of 9 died. This is in contrast to prior reports suggesting no known mortality among pregnant women infected by SARS-CoV-2

Comment Taskforce Knowledge-Management Covid-19

Trotz 2.5 Millionen Infizierten und 169’000 Todesfälle weltweit (Stand 20. April 2020) wurden keine maternalen Todesfälle während Schwangerschaften im Zusammenhang mit COVID-19 Infektionen beschrieben. Dies ist umso erstaunlicher, weil im Rahmen anderer Coronavirus-Infektionen (SARS-CoV in 2003 and MERS-CoV) oder Influenza-Pandemien eine deutlich höhere maternale Mortalität beobachtet wurde. In dieser Studie aus Iran wurden jedoch sieben COVID-19-assozierte Todesfälle identifiziert. Daher ist die Mortalität für infizierte Schwangere nicht gleich Null.

#clinical #obstetrics & gynaecology
04.05.2020

Inhibitors of the Renin-Angiotensin-Aldosterone System and Covid-19.

Three cohort studies were simultaneously published in the NEJM on the single topic of angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) in the Covid-19 pandemic. These studies do not provide evidence to support the hypothesis that ACE inhibitor or ARB use is associated with the risk of SARS-CoV-2 infection, the risk of severe Covid-19 among those infected, or the risk of in-hospital death among those with a positive test.

#clinical #prevention #general #cardiology #cardiovascular #nephrology #diabetes #cerebrovascular #internal medicine #epidemiology
03.05.2020

Children with Covid-19 in Pediatric Emergency Departments in Italy

First larger pediatric ER case series (100 patients) from a European country. Mild course in most cases; ICU 1 patient; death 0 patients.

Comment Taskforce Knowledge-Management Covid-19

Sorgfältiger Vergleich mit den grössten Studien aus China ergibt ähnliches klinisches Bild mit fast ausschliesslich milden Verläufen, auch für Kinder mit Vorerkrankungen.

#clinical #infectious diseases #pediatrics
02.05.2020

What Happens Next?

Associate Professor from EPFL and graphics/code artist present extensive and elaborate simulations on where the COVID-19 pandemic comes from, what will happen IF, and the implications of all those simulations. Extensive educational resource to help you comprehend, why all that stuff is going on around us.

Comment Taskforce Knowledge-Management Covid-19

Hervorragend aufbereitete, wissenschaftlich fundierte, gut belegte und vor allem laienverständliche Simulationen. Alles Drin: R0, R, lockdown, Händewaschen, Masken tragen, Impfen - einfach alles. Sogar Sommer.

#general #prevention #medical education #epidemiology
02.05.2020

Shedding of infectious SARS-CoV-2 in symptomatic neonates, children and adolescents

Researchers from Geneva demonstrate that 50% of SARS-CoV-2 PCR positive children of all ages also sheded viable (in vitro cultured) virus, which is potentially infectious. Culture positivity correlated positively with viral RNA copy number

Comment Taskforce Knowledge-Management Covid-19

Diese interessante in vitro Studie suggeriert, dass nur ein ein Teil der PCR positiven Proben infektiös sind, v.a. diejenigen mit hoher Kopienzahl

#diagnosis #prevention #infectious diseases #pediatrics #neonatology
01.05.2020

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China.

In this retrospective, single-center case series of the 1'178 hospitalized patients with COVID-19 infections at the Central Hospital of Wuhan, China, involving 362 patients with hypertension, no difference in severity of the disease, complications, and risk of death in those who were taking ACEIs/ARBs, compared with those not treated with these medications was observed.

Comment Taskforce Knowledge-Management Covid-19

In dieser retrospektiven Studie zeigt sich, dass Patienten mit einer arteriellen Hypertonie, welche mittels ACE Hemmer oder Angiotensin Rezeptor Blocker behandelt wurden, keinen schlechteren Verlauf von Covid-19 haben im Vergleich zu den Patienten, welche mit anderen Medikamenten behandelt wurden. Dies ist beruhigend und demnach sollten Patienten mit einer arteriellen Hypertonie ihre Medikamente unverndert weiter einnehmen.

#prevention #therapy #general #cardiology #cardiovascular #nephrology #diabetes #cerebrovascular
30.04.2020

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

First published randomized trial evaluating remdesivir vs. placebo in hospitalized patients from China. No impact of remdesivir on time to clinical improvement or viral load. Larger trials are needed to show a potential beneficial impact if remdesivir is started early

Comment Taskforce Knowledge-Management Covid-19

Negative Resultate bei der ersten randomisierten Studie zu remdesivir. Möglicher Klinischer Benefit bei Gabe von Remdesivir wenn Symptome <10 Tage muss in grösseren Trials bestätigt werden.

#treatment #infectious diseases #internal medicine
30.04.2020

Covid-19: What do we know so far about a vaccine?

An accurate one-page summary of the current status of vaccine development against SARS-CoV-2

#prevention #infectious diseases
29.04.2020

The race for coronavirus vaccines: a graphical guide.

Eight ways in which scientists hope to provide immunity to SARS-CoV-2

Comment Taskforce Knowledge-Management Covid-19

Illustrative Arbeit über die verschiedenen Strategien zur Erforschung und Bereitstellung eines Impfstoffes

#prevention #general
29.04.2020

Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals.

Hospital toilets can be a hotspot for airborne viral RNA. The new coronavirus’s RNA can travel through the air, and might spread by way of small particles exhaled by infected people. The team detected elevated levels of viral RNA in locations such as a small toilet used by patients, and staff changing rooms. No viral RNA was detected in staff rooms after they had been disinfected. Low to undetectable levels were found in the hospitals’ well-ventilated patient wards. They suggest that measures such as routine disinfection and better ventilation could help to control the virus’s spread

Comment Taskforce Knowledge-Management Covid-19

Die Studie aus Wuhan über Spitaltoiletten weist auf ein Porblem hin, das möglicherweise gerade in kleineren, dezentralen Arztpraxen noch mehr beachtet werden könnte