COVID-19

Publications and Guidelines

31.03.2020

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic

State of the art review article about COVID-19 and cardiovascular disease

#guidelines #cardiovascular #cardiology
31.03.2020

Preventing a covid-19 pandemic: ACE inhibitors as a potential risk factor for fatal Covid-19

Sommerstein/Gräni from the Inselspital were questioning whether ACE inhibitors upregulate ACE2, the entry receptor for Sars-CoV2 and may worsen the course?

#prevention #treatment #cardiovascular #diabetes #cardiology
31.03.2020

Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers

Due to the concern of patients and healthcare providers regarding uncertainties with ACEI/ARBs in Covid-19, a statement was released: ACEI/ARBs should be continued and treatment should not be changed as no evidence is available that they do harm in Covid-19. ACEI/ARBs should be given according to established guidelines.

#guidelines #cardiology
31.03.2020

Recommendations for Endotracheal Intubation of COVID-19 Patients

Anesthesia induction is a precedure with a high risk of aerosolization of SARS-CoV-2. This article discribes how anesthesia induction should be modified in order to minmize this risk. This article is short and reflects the positions of the major societies

#treatment #guidelines #anaesthesiology
31.03.2020

COVID-19 pandemic: triage for intensive-care treatment under resource scarcity

Although not a being a scientific paper, this special article provides decision guidance for the allocation of ICU treatment in the face of scarce ressources with a potentially upcoming wave of COVID-19 patients requiring ICU support in Switzerland

#treatment #guidelines #ICU
30.03.2020

Joint Statement on Multiple Patients Per Ventilator

Several countries that face a mismatch between existing ventilatory infrastructure and demand for ventilator support of critical COVID-19 patients in ICU start developing custom-made solutions to overcome this problem. Some of these include ventilating two or more patients with the same ventilator. The Anaesthesia Safety Foundation (APSF) has released a statement that discourages these modifications and provides solid arguments against such solutions. This statement has been endorsed by several other major organizations.

#treatment #guidelines #ICU #anaesthesiology
30.03.2020

Not wearing masks to protect against coronavirus is a ‘big mistake,’ top Chinese scientist says

Interesting interview with George Gao, head of the Chinese Center for Disease Control and Prevention

#prevention #general #epidemiology
30.03.2020

Clinical and immunologic features in severe and moderate Coronavirus Disease 2019

Analyse von immunologischen Faktoren im peripheren Blut bei 21 Paitenten mit mittelschwerer bis schwerer COVID-Infektion zum Zeitpunkt des Spitaleintritts. Patienten mit schwerem Verlauf (SpO2<93%, Tachypnoe oder beatmungspflichtig) wiesen höhere Werte an IL-2R, IL-6, IL-10 und TNF-a auf, zudem eine absolute Lymphopenie, welche vorwiegend auf eine Reduktion von CD4+ und CD8+ T Zellen zurückgeführt wurde.

Comment Taskforce Knowledge-Management Covid-19

Wenngleich diese Parameter nicht spezifisch für COVID19 Infektionen sind und im Allgemeinen Ausdruck einer schweren viralen Infekten, könnten sie zur frühzeitigen Beurteilung von Therapiebedarf und Einschätzung des Outcomes bei COVID19-erkrankten Patienten berücksichtigt werden.

#treatment #ICU #immunoresponses
30.03.2020

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

Safety and effectivity of covalescent plasma in 5 patients with ventilation-dependent COVID infection

#treatment #ICU
30.03.2020

Convalescent Plasma to Limit Coronavirus Associated Complications: An Open Label, Phase 2A Study of High-Titer Anti-SARS-CoV-2 Plasma in Hospitalized Patients With COVID-19

Open label, single arm trial with covalescent plasma, 1-2 units with anti-CoV2 titer >1:64. Endpoint: RNA Change, ICU admision, hospital Mortality, Hospital Lenthg

#treatment #ICU