Publications and Guidelines


Coronavirus Disease 2019 (COVID‐19): Do Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Have a Biphasic Effect?

Cardiologists and infectiologists from the the Inselspital comment on the possible biphasic effect of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Covid-19.

Comment Taskforce Knowledge-Management Covid-19

Die Autoren stellen eine Hypothese auf, welche besagt, dass ACE Hemmer und Angiotensin-Rezeptor Blocker einerseit den Eintritt des Virus in die Zellen via ACE2 up-regulation begünstigen könnten. Andererseits wäre eine up-regulation des ACE2 bei bereits infizierten Patienten mit diesen Medikamenten erwünscht um das lungenschädigende Angiotensin II tief zu halten. Sicherlich muss eine solche Hypothese mittels Studien genau untersucht werden und bis dahin sollte nichts an der Medikation verändert werden.

#general #clinical #cardiovascular #infectious diseases

Angiotensin Converting Enzyme 2: A Double-Edged Sword

The authors describe the bifunctional role of ACE2 as a “double-edged sword”, which turns off the renin-angiotensin system and leads to beneficial effects but also mediates unique susceptibility to lung and cardiovascular disease in COVID-19 patients by serving as the SARS-CoV-2 receptor.

#cardiovascular #pneumology

Loss of smell and taste in combination

App based large scale UK study demonstrates that loss of smell accompanied 59% of SARS-CoV-2 positive cases, but only 18% of negative cases with similar other symptoms

Comment Taskforce Knowledge-Management Covid-19

Gut gemachte Studie unterstützt Berichte, dass SARS-CoV-2 Infektion deutlich häufiger mit akuter Anosmie assoziiert ist als andere virale Atemwegsinfektionen.

#general #clinical #infectious diseases

Behavioral and Emotional Disorders in Children during the COVID-19 Epidemic

Clinginess, inattention, irritability and fear of asking questions about the epidemic are reported as major psychological reactions among children > 3 years of age in China.

Comment Taskforce Knowledge-Management Covid-19

Kinder in China reagierten in dieser Elternumfrage v.a. mit Anhänglichkeit, Aufmerksamkeitsstörung, Reizbarkeit und Angst Fragen zu stellen auf die veränderten Lebensbedingungen während des Lock-downs.

#general #pediatrics

Predictor of COVID-19 infection

Ferguson and colleagues from the Imperial College London estimate with infection propagation models that, across 11 countries between 7 and 43 million individuals have been infected with SARS-CoV-2 up to 28th March, representing between 1.9% and 11.4% of the population. With current government interventions remaining in place, they estimated that interventions across all 11 countries will have averted 59,000 deaths up to 31 March [95% uncertainty range 21,000-120,000].

Comment Taskforce Knowledge-Management Covid-19

Ferguson and colleagues from the Imperial College London have done some serious modelling work to estimate how much government measures in 11 European countries reduced the basic reproduction number of SARS-CoV-2 infections. Also Switzerland is covered and the “lockdown” might have brought it down near 1 (with substantial uncertainty). They estimate that Swiss measures might have averted 340 deaths by March 31 [95% uncertainty range: 71 - 1,100].


Developing antibody tests for SARS-CoV-2

In response to the COVID-19 pandemic, laboratories are rushing to produce reliable antibody tests. Antibodies are markers of a previous infection and they can be found in a patient’s blood sample any time from about a week after the infection happened. The most highly anticipated expectation of antibody tests to COVID-19 is to understand how many cases of COVID-19 have actually occurred in a population.

Comment Taskforce Knowledge-Management Covid-19

Übersichtlicher Artikel zur Entwicklung, Verfügbarkeit und Rolle von zuverlässigen Antikörper-Tests für SARS-CoV-2.

#general #diagnosis #therapy

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

Out of 416 hospitalized patients with COVID-19 in Wuhan, China, 19.7% had cardiac injury, and were at a significant higher risk of death compared with patients without cardiac injury. Although the exact mechanism of cardiac injury needs to be further explored, the findings presented here highlight the need to consider this complication in COVID-19 management.

#diagnosis #cardiovascular #ICU

Potential Effects of Coronaviruses on the Cardiovascular SystemA Review

This review about the Coronavirus disease 2019 gives the reader information how Covid-19 is associated with a high inflammatory burden that can induce vascular inflammation, myocarditis, and cardiac arrhythmias.

#review #cardiovascular #cardiology

COVID-19 patients and the Radiology department – advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI)

In their official statement, the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI) summarise main imaging findings of COVID-19, provide advice on the role of CT in the early diagnosis of COVID-19, and offer guidance on organisational measures for radiology departments during this pandemic.

Comment Taskforce Knowledge-Management Covid-19

Sehr übersichtliches Resümee zur Rolle der Radiologie bei Diagnose und Management von COVID-19 Patienten sowie Erläuterungen zu Schutzmassnahmen für Gesundheitspersonal, verfasst von der Europäischen Gesellschaft für Radiologie.

#imaging #consensus statement #radiology

COVID-19 Pandemic, Corona Viruses, and Diabetes Mellitus

Older age and the presence of diabetes, hypertension, and severe obesity increases morbidity and mortality in patients with COVID-19. Considering the high prevalence of cardiovascular disease, obesity, and hypertension in patients with DM, it is unknown whether diabetes independently contributes to this increased risk. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Novel ways to deliver care to our diabetes patients using telehealth, remote patient monitoring, and wearable technologies are needed.

#general #diabetes #endocrinology