COVID-19

Le et al. give an overview of the COVID-19 vaccine discovery by early April 2020. 73 condirmed and active vaccine candidates have been developed across the world, of whom 5 are already in clinical phase I studies. Overall, 56 (72%) are being developed by private/industry developers and 22 by the public/academic sector

Discussion of evidence showing possible distribution of SARS-COV-2 via aerosols and feces

The presented approaches provide flexibility and allow perinatal health care providers and parents to determine the best options based on the assessment of risks and benefits, available personnel, space, case load, and resources. In the pandemic of COVID-19, the common ailments of neonates will remain higher on the differential diagnosis. However, the possibility of infection from SARS-CoV-2 should be considered in the ill infant for the foreseeable future. It is also of prime importance that health care providers protect themselves while providing the best care possible.

Ein online symptom checker, der eine recht detaillierte Anamnese erhebt und eine individuelle Entscheidungsunterstützung liefert. Entwickelt von der in4medicine in Bern, in zusammenarbeit mit zahlreichen internationalem Partnern, inklusive der eNotfallmedizin des Inselspitals.

Although the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 and perinatal deaths were reported. Vertical transmission of the COVID-19 could not be ruled out. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.

In this study with 103 patients under investigation for COVID-19 initial CT had a high sensitivity but specificity and the negative predictive value were only modest. These findings add to the growing body of evidence that CT has a low value as screening tool for COVID-19.

The consensus statement of this international, multidisciplinary panel provides guidance on the current role of imaging during the COIVD-19 pandemic, clearly summarized in flow-charts for different scenarios.

10 patients with severe COVID-19 infection were given convalescent plasma in addition to standard care after a median time of 16.5 days of symptoms. The infusions were well tolerated and could significantly increase or maintain the neutralizing antibodies at a high level, leading to disappearance of viremia in 7 days. Several clinical and laboratory parameters improved rapidly.

The authors of this article propose the use of clear plastic drapes for extubation to reduce the spread of droplets during extubation

This CPR simulator model and cadaver study for chest-compressions during CPR showed that chest-compression only CPR has a high risk for aerosol spread. Endotracheal intubation itself however also has a high risk of aerosolization. Insertion of a laryngeal tube with HEPA-filter during CPR may lead to improved oxygenation and protect health care providers.