Publications and Guidelines


Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility

This review summarizes the clinical and preclinical evidence for the existence of elevated plasmin(ogen) in important comorbid conditions of COVID-19, like hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction, and highlights the importance of plasmin-induced proteolytic cleavage of the SARS-COV-2 S protein and fibrin in the development of COVID-19. Plasminogen might be a possible common denominator in the understanding of the mechanisms for high morbidity and mortality of patients with important comorbid conditions, could be an independent factor for risk stratification and a possible therapeutic target in COVID-19.

#general #internal medicine #physiology

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

Retrospective study raising awareness for gastrointestinal symptoms in COVID-19 patients. Analyzing the largest cohort of patients with GI symptoms to date, this study found novel characteristics of COVID-19, including increased family clustering and liver injury, severe/critical type tendency and higher rate of body temperature >38.5°C, holding important implications for healthcare workers not to overlook on this possible form of presentation in COVID-19.

#gastrointestinal #epidemiology

Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic

State of the art review article about COVID-19 and cardiovascular disease

#guidelines #cardiovascular #cardiology

Preventing a covid-19 pandemic: ACE inhibitors as a potential risk factor for fatal Covid-19

Sommerstein/Gräni from the Inselspital were questioning whether ACE inhibitors upregulate ACE2, the entry receptor for Sars-CoV2 and may worsen the course?

#prevention #treatment #cardiovascular #diabetes #cardiology

Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers

Due to the concern of patients and healthcare providers regarding uncertainties with ACEI/ARBs in Covid-19, a statement was released: ACEI/ARBs should be continued and treatment should not be changed as no evidence is available that they do harm in Covid-19. ACEI/ARBs should be given according to established guidelines.

#guidelines #cardiology

Recommendations for Endotracheal Intubation of COVID-19 Patients

Anesthesia induction is a precedure with a high risk of aerosolization of SARS-CoV-2. This article discribes how anesthesia induction should be modified in order to minmize this risk. This article is short and reflects the positions of the major societies

#treatment #guidelines #anaesthesiology

COVID-19 pandemic: triage for intensive-care treatment under resource scarcity

Although not a being a scientific paper, this special article provides decision guidance for the allocation of ICU treatment in the face of scarce ressources with a potentially upcoming wave of COVID-19 patients requiring ICU support in Switzerland

#treatment #guidelines #ICU

Joint Statement on Multiple Patients Per Ventilator

Several countries that face a mismatch between existing ventilatory infrastructure and demand for ventilator support of critical COVID-19 patients in ICU start developing custom-made solutions to overcome this problem. Some of these include ventilating two or more patients with the same ventilator. The Anaesthesia Safety Foundation (APSF) has released a statement that discourages these modifications and provides solid arguments against such solutions. This statement has been endorsed by several other major organizations.

#treatment #guidelines #ICU #anaesthesiology

Not wearing masks to protect against coronavirus is a ‘big mistake,’ top Chinese scientist says

Interesting interview with George Gao, head of the Chinese Center for Disease Control and Prevention

#prevention #general #epidemiology

Clinical and immunologic features in severe and moderate Coronavirus Disease 2019

Analyse von immunologischen Faktoren im peripheren Blut bei 21 Paitenten mit mittelschwerer bis schwerer COVID-Infektion zum Zeitpunkt des Spitaleintritts. Patienten mit schwerem Verlauf (SpO2<93%, Tachypnoe oder beatmungspflichtig) wiesen höhere Werte an IL-2R, IL-6, IL-10 und TNF-a auf, zudem eine absolute Lymphopenie, welche vorwiegend auf eine Reduktion von CD4+ und CD8+ T Zellen zurückgeführt wurde.

Comment Taskforce Knowledge-Management Covid-19

Wenngleich diese Parameter nicht spezifisch für COVID19 Infektionen sind und im Allgemeinen Ausdruck einer schweren viralen Infekten, könnten sie zur frühzeitigen Beurteilung von Therapiebedarf und Einschätzung des Outcomes bei COVID19-erkrankten Patienten berücksichtigt werden.

#treatment #ICU #immunoresponses