COVID-19

Publications and Guidelines

02.03.2021

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Both IL-6 antagonists tocilizumab and sarilumab improved survival in critically ill patients in a randomized controlled trial.

Comment Knowledge-Management Taskforce Covid-19

Die klinische Beobachtung hoher IL-6 Werte in schwer erkrankten COVID-19 wurde bereits mechanistisch in experimentellen Studien validiert. Mit dieser randomisierten Studie wurde jetzt der Weg für eine klinische Anwendung geebnet.

#therapy #clinical #treatment #ICU
28.02.2021

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

A “real world” analysis of the effectiveness of the BNT162b2 mRNA vaccine in Israel including almost 600 000 persons who were newly vaccinated during the period December 20, 2020 to February 1, 2021(compared to a carefully matched group of unvaccinated persons). Similar to the RCT results, the vaccine was effective for a wide range of Covid-19–related outcomes and estimated an effectiveness in preventing death from Covid-19 as 72% (95% CI, 19 to 100).

Comment Knowledge-Management Taskforce Covid-19

Diese sehr solid gemachte “real world effectiveness» Studie bestätigt die Wirksamkeit der Biontech Impfung. Dank eines sehr gut organisierten digital aufgestellten Gesundheitssystems in Israel konnte diese Studie unglaublich schnell durchgeführt werden.

#prevention #emergency medicine #epidemiology
17.02.2021

Development and validation of a prognostic COVID-19 severity assessment (COSA) score and machine learning models for patient triage at a tertiary hospital

The authors developed and validated an easy to use prediction score, that allows to predict the likelihood of adverse clinical outcomes (ICU admission or death) from routine laboratory data in patients with COVID-19. Their score has very good predictive performance (AUROC = 0.85, PPV = 0.91, NPV = 0.81). They also provide access to a simple online score calculator.

Comment Knowledge-Management Taskforce Covid-19

Artikel zu einer komplexen Score-Entwicklung und -Validierung, mit aber praktisch sehr nützlichem Ergebnis: einem Score, der anhand von wenigen Routineparametern einen schweren COVID-Verlauf gut vorhersagen kann. Nützlich vor allem ausserhalb von Zentrumsspitälern.

#diagnosis #general #clinical #internal medicine #ICU #emergency medicine
09.02.2021

Seroprevalence of anti-SARS-CoV-2 antibodies after the second pandemic peak

Geneva's second wave seroprevalence study reveals overall SARS-Cov-2 positivity of 21% of the population with children <5 and adults >65 years being > 40% less likely to have been infected.

Comment Knowledge-Mangement Taskforce Covid-19

Die Studie zeigt, dass auch die 2. Welle bisher keine bezüglich Herdimmunität relevante Durchseuchung gebracht hat und Risikopersonen weiterhin zu >80% ungeschützt sind.

#publication #general #infectious diseases #immunoresponses
25.01.2021

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

Phase 2 trial that tested use of monoclonal antibodies in patients with mild or moderate COVID-19. Patients who received LY-CoV555 hat lower viral titers and slightly lower severity of symptoms compared to placebo.

Comment Knowledge-Management Taskforce Covid-19

Diese Studie bietet erste Hinweise, dass die Gabe monoklonale Antikörper in einem frühen Stadium den Krankheitsverlauf mildern kann.

#treatment #immunoresponses
13.01.2021

Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis

In this systematic review 936 neonates from mothers with coronavirus disease 2019, 27 neonates had a positive result for severe acute respiratory syndrome coronavirus 2 viral RNA test using nasopharyngeal swab, indicating a pooled proportion of 3.2% for vertical transmission.

Comment Knowledge-Management Taskforce Covid-19

Dieser systematische Review zeigte, dass im 3. Trimester der Schwangerschaft eine SARS-CoV-2-Infektion mit einer tiefen Rate einer vertikalen Transmission assoziiert war; ungefähr 3.2%. Diese neonatale Infektion hatte für die Säuglinge keine signifikante Konsequenz. Unklar ist jedoch, ob die vertikale Transmissionsrate mit dem Schwangerschaftsalter variiert und ob eine Transmission im 1. Trimester einen teratogenen Effekt auf den Fetus haben könnte.

#review #obstetrics & gynaecology #neonatology
13.01.2021

Management Considerations for Pregnant Patients With COVID-19

The COVID-19 pandemic has placed extreme stress on the national health care system. As the epidemiology of COVID-19 evolves, obstetrical care providers must manage pregnant patients with COVID-19 in the setting of little to no experience or rigorous data from which to develop protocols and guidance.

Comment Knowledge-Management Taskforce Covid-19

Umfassende Abhandlung bezüglich der Betreuung von Schwangeren mit COVID-19-Infektion; herausgegeben von der internationalen “Society for Maternal-Fetal Medicine”

#guidelines #obstetrics & gynaecology #neonatology
12.01.2021

Pulmonary function and radiological features four months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

In this Swiss multi-center study 47 patients after mild/moderate and 66 patients after severe/critical SARS-CoV-2 infection were followed up 4 months after recovery. In the patient group with a severe/critical course there were significantly more patients with a higher BMI, higher age, hypertension, diabetes and renal failure. A severe/critical condition during COVID-19 was associated with decreased pulmonary function as assessed by predicted % diffusion of carbon monoxide (DLCO), reduced distance during a 6 minutes walking test and exercise induced blood oxygen desaturation at 4 months follow up. Mosaic hypoattenuation in chest CT was significantly associated with severe/critical disease progression of COVID-19. Importantly, predicted % DLCO was the strongest and most important correlate for a severe/critical condition during COVID-19 infection, which may explain the reduced walking distance and desaturation during exercise. According to the authors this is the first European prospective longitudinal cohort study to understand the sequelae and different functional trajectories of COVID-19 patients.

Comment Knowledge-Management Taskforce Covid-19

113 COVID-19-Überlebende wurden in der Studie eingeschlossen (leicht/mittelschwer 47, schwer /kritisch 66). Es wurden mehrere Komorbiditäten als Risikofaktoren für einen schweren/kritischen Krankheitsverlauf identifiziert.

#general #publication #infectious diseases #pneumology
07.01.2021

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Analysis of persisting anti-SARS CoV2 humoral, B- and T-cell immunity in 188 patients with mild to moderate COVID-Infection

Comment Knowledge-Mangement Taskforce Covid-19

Humorale, B- und T-Zellimmunität bleibt in der Mehrzahl der Patienten erhalten >6 Monate nach einer COVID-19 Erkrankung.

#general #infectious diseases #immunoresponses
02.01.2021

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

Phase III results for the second COVID-19 mRNA vaccine (Moderna, mRNA-1273) demonstrate a similar performance compared with the Pfizer/Biontech BNT162b2 vaccine. Overall vaccine efficacy over 2 months after dose 2 was 94.1% with no differences according to gender, ethnicity and presence of risk factors. Efficacy > 65 years was somewhat lower (86%). Reactogenicity as to be expected, no severe adverse events reported.

Comment Knowledge-Management Taskforce Covid-19

Die Daten erhärten die hohe Kurzzeit-Immunogenität und Schutzwirkung von COVID-19 mRNA Impfstoffen mit 2 priming Dosen innert 3-4 Wochen bei guter Tolerabilität. Preliminäre Daten suggerieren zusätzlich Potential für Schutz vor asymptomatischer Infektion nach Dosis 1.

#vaccine #prevention #infectious diseases #immunoresponses